TOPLINE:
In children being treated for type 1 diabetes, hyperpigmentation at sites of insulin injection and glucose monitoring may signal Addison disease.
METHODOLOGY:
- A case report describing a 12-year-old child with type 1 diabetes and coeliac disease.
- For 2-3 months, the skin had been darkening at sites of the insulin pump cannula and continuous glucose monitor.
- Sites had also been itching, consistent with allergic contact dermatitis.
- Skin was also darkening around the mouth and on the knuckles.
- The child was gaining weight to the 98th and height to the 50th percentiles but lacked symptoms of adrenal insufficiency.
TAKEAWAY:
- Cortisol and adrenocorticotropic hormone levels were consistent with primary adrenal insufficiency.
- Serum sodium, aldosterone, and renin levels were consistent with mineralocorticoid deficiency.
- Addison disease was confirmed by the presence of adrenal antibodies.
- The child was treated with hydrocortisone and fludrocortisone for several months, because of which darkened skin patches faded.
IN PRACTICE:
“Allergic dermatitis may have contributed, but hyperpigmentation from diabetes technology dressings and elsewhere should raise concerns regarding Addison’s disease,” the authors wrote.
SOURCE:
The study was authored by clinicians at the University Hospital Southampton, Southampton, UK, and the report appeared in the Archives of Disease in Childhood.
LIMITATIONS:
This is a single-case study.
DISCLOSURES:
The lead author Rebecca J. Moon received funding from the Health Education England/National Institute for Health and Care Research as an academic lecturer. The authors reported no conflicts of interest.
Source link : https://www.medscape.com/s/viewarticle/hyperpigmentation-diabetes-treatment-sites-may-flag-2024a100031a?src=rss
Author :
Publish date : 2024-02-15 14:00:00
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