Leaky Blood Vessels and Long COVID; BCG Vaccine and Alzheimer’s; New CTE Subtype

Brain fog in long COVID may be due to a leaky blood-brain barrier, new research suggested. (Nature Neuroscience)

A highly accurate novel blood test was at least as good as FDA-approved cerebrospinal fluid assays at diagnosing Alzheimer’s disease. (Nature Medicine)

Traffic-related fine particulate matter was tied to Alzheimer’s pathology at autopsy, especially in people who did not carry an APOE4 allele. (Neurology)

Diagnoses of Parkinson’s disease and cancers related to trichloroethylene appeared to be elevated among attorneys who worked near a contaminated dry-cleaning site. (Movement Disorders)

Can the bacille Calmette-Guérin (BCG) vaccine protect against Alzheimer’s disease? (The Guardian)

Dementia risk associated with post-traumatic epilepsy was significantly higher than dementia risk associated with head injury or seizures alone. (JAMA Neurology)

Researchers identified a potential new subtype of chronic traumatic encephalopathy (CTE) called cortical-sparing CTE. (Acta Neuropathologica)

People with multiple sclerosis had nearly twice the risk of seizures as the general population, according to a meta-analysis. (Journal of Neurology, Neurosurgery, and Psychiatry)

Artificial intelligence helped identify Alzheimer’s risk from electronic health records. (Nature Aging)

As clinicians and patients await the FDA’s decision about the investigational anti-amyloid agent donanemab, Endpoints News looked at the $8 billion investment Eli Lilly has made in Alzheimer’s drugs.

Researchers mapped dysfunctional circuits in the frontal cortex in Parkinson’s disease, dystonia, obsessive-compulsive disorder, and Tourette’s syndrome using deep brain stimulation. (Nature Neuroscience)

Should a retired neurologist offer an unsolicited medical diagnosis? (New York Times)

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