Gabapentinoid use significantly increased the risk for exacerbations in adults with chronic obstructive pulmonary disease (COPD).
- Previous research has prompted warnings from North American and European health agencies of severe exacerbations associated with gabapentinoid use by patients with COPD.
- The researchers compared data from patients with COPD in Canadian databases between 1994 and 2015 who were new to gabapentinoids and matched them to patients who did not use gabapentinoids.
- The primary outcome was exacerbation of COPD that required hospitalization in a propensity score-matched study.
- The study population included 356 epilepsy patients, 9411 neuropathic pain patients, and 3737 patients with other chronic pain.
- Use of gabapentinoids was significantly associated with an overall increased risk for severe COPD exacerbation (hazard ratio, 1.49) compared with nonuse.
- Gabapentinoid use was associated with a significantly increased COPD exacerbation risk for each group of users compared with nonusers, with hazard ratios of 1.58, 1.35, and 1.49 for epilepsy, neuropathic pain, and other chronic pain, respectively.
“This study supports the warnings from regulatory agencies and highlights the importance of considering this potential risk when prescribing gabapentin and pregabalin to patients with COPD,” the researchers wrote.
The lead author on the study was Alvi A. Rahman, MSc, of Jewish General Hospital, Montreal, Canada. The study was published online on January 16, 2024, in the Annals of Internal Medicine.
A lack of data on smoking status and other residual confounding factors limited the study findings.
The study was supported by the Canadian Institutes of Health Research and the Canadian Lung Association. Rahman had no financial conflicts to disclose, but some coauthors disclosed consulting and advisory relationships with various companies, including Merck, Pfizer, Seqirus, Boehringer-Ingelheim, and Novartis outside of the current work.
Source link : https://www.medscape.com/viewarticle/gabapentinoids-increase-exacerbation-copd-2024a10002bu?src=rss
Publish date : 2024-02-02 10:28:39
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