Alzheimer’s Pathology and COVID; Human Brain Cell Maps Unveiled; TCE Ban Proposed

Researchers teased apart possible relationships between COVID-19 and Alzheimer’s disease pathology. (Journal of Neurochemistry)

COVID infection was tied to an increased risk of a diagnosis of Guillain-Barré syndrome within 6 weeks, while mRNA vaccination was linked with a decreased risk. (Neurology)

Scientists from the NIH BRAIN Initiative Cell Census Network unveiled detailed cell maps of the human brain in a collection of 24 papers published in Science, Science Advances, and Science Translational Medicine.

CMS relaxed its PET beta amyloid imaging restrictions for dementia and neurodegenerative diseases, opening the door for wider use of scans in prescribing anti-amyloid monoclonal antibodies for early Alzheimer’s disease.

The EPA proposed banning trichloroethylene (TCE), which has been linked to cancer and neurotoxicity, including Parkinson’s disease.

Attention-deficit/hyperactivity disorder (ADHD) in adults was associated with an increased risk of dementia. (JAMA Network Open)

Prenatal lead exposure and its interaction with genetic factors might jointly contribute to the risk of cognitive development delay, observational data in China showed. (JAMA Network Open)

People who were sleeping could respond to verbal stimuli. (Nature Neuroscience)

Ten predictors were strongly associated with opioid overdose. (CMAJ)

Hippocampal functions of making associations versus planning future actions were separable in rats. (Science)

Treating APOE4-tauopathy mice with HMGB1 inhibitors ameliorated the development of APOE4-driven gliosis, tau pathology, neurodegeneration, and myelin deficits. (Cell Reports)

Post-zygotic rescue of meiotic errors may cause brain mosaicism and focal epilepsy, brain tissue analyses suggested. (Nature Genetics)

A cardiologist confronted the paradox of advanced directives when his father was dying with dementia. (New York Times)