Search Results for: breast cancer

DCIS Tied to Higher Chance of Breast Cancer Death

Women with a ductal carcinoma in situ (DCIS) diagnosis were over three times more likely to die from breast cancer versus those in the general population, a retrospective study found. In over 140,000 women who underwent surgery after being diagnosed with DCIS, 1,540 died from invasive breast cancer compared with an expected 458 for cancer-free women (standardized mortality ratio [SMR] …

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Breast cancer: One-dose radiotherapy ‘as effective as full course’

Image copyright Getty Images A single targeted dose of radiotherapy could be as effective at treating breast cancer as a full course, a long-term study suggests. Researchers said people who received the shorter treatment were also less likely to die of other cancers and heart disease in the following five years. But cancer specialists have raised concerns about the study’s …

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Survival Effect of pCR Elusive in Breast Cancer

Neoadjuvant therapy that resulted in pathologic complete response (pCR) reduced the risk of breast cancer recurrence by 80%, pooled data from a phase II clinical trial platform showed. The results held up across all breast cancer subtypes and treatment regimens, which included nine novel combinations. About a third of patients achieved pCR with neoadjuvant therapy, and those patients had 3-year …

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Older Age Should Not Rule Out Chemo in Breast Cancer Patients

Elderly women benefitted from undergoing adjuvant chemotherapy for their node-positive, estrogen receptor-positive breast cancer, even in the presence of multiple comorbidities, retrospective data suggested. A large study of 1,592 patients in the U.S. National Cancer Database from 2010 to 2014 showed that after adjustment for other risk factors, women ages 70 and older who underwent chemotherapy (n=350) for breast cancer …

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Tucatinib Prolongs Survival in Breast Cancer With Brain Mets

Adding tucatinib (Tukysa) to a trastuzumab-capecitabine (Herceptin-Xeloda) regimen significantly improved central nervous system outcomes versus placebo plus trastuzumab-capecitabine in patients with HER2-positive metastatic breast cancer and brain metastases at baseline, researchers reported at the 2020 American Society of Clinical Oncology virtual scientific meeting. In this exclusive MedPage Today video, Amy Tiersten, MD, of Mount Sinai Hospital in New York City, …

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MI May Fuel Breast Cancer Recurrence, Mortality

In survivors of early breast cancer, cardiovascular events significantly increased the risk of cancer recurrence and cancer death, a review of 1,700 patients showed. The risk of breast cancer recurrence increased by 59% and cancer-specific death by 60% in patients who had a heart attack, stroke, or heart failure after cancer diagnosis and treatment. Laboratory studies involving a preclinical model …

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More Convenient Treatment for HER2+ Breast Cancer

Women with HER2-positive breast cancer will soon have a more convenient option for a widely used treatment, currently available only by infusion, as a result of FDA approval of the fixed-dose combination Phesgo. Phesgo consists of pertuzumab (Perjeta), trastuzumab (Herceptin), and hyaluronidase-zzxf for subcutaneous injection. Initially administered along with chemotherapy, Phesgo maintenance treatment could continue at home with the assistance …

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Brief Quasi-Fasting Diet Boosts Breast Cancer Chemo Response

A fasting mimicking diet (FMD) – a low-calorie, low-protein, plant-based, intermittent meal plan with the metabolic benefits of fasting — used over several days was a safe and effective adjunct to chemotherapy in women with early breast cancer, a randomized trial showed. FMD significantly boosted the effects of neoadjuvant chemotherapy on the radiological and pathological tumor response in women with …

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‘Unbelievably Exciting’ Results in Rare Type of Breast Cancer

Metaplastic breast cancer (MpBC) is a rare form of triple-negative breast cancer (TNBC), accounting for fewer than 1% of all breast cancers, but it is very aggressive and responds poorly to chemotherapy. So new results with a combination of immunotherapies that resulted in significant tumor shrinkage and survival topping 2 years have led to some excitement, even though the results …

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Clinical Challenges: ADCs and Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) — i.e., breast cancer that does not express estrogen, progesterone, or HER2 receptors — comprises approximately 10%-20% of all breast cancers and represents “an unmet need in the field of breast oncology,” said Aditya Bardia, MD, MPH, director of precision medicine at the Center for Breast Cancer at Massachusetts General Hospital Cancer Center and Harvard Medical …

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ASCO Roundtable: Advances in Breast Cancer

At the 2020 American Society of Clinical Oncology’s virtual scientific meeting, over 100 sessions and thousands of abstracts on the latest emerging topics in cancer treatment were presented in all-virtual format. MedPage Today has brought together three expert leaders in their field: Sara Tolaney, MD, a breast oncologist at Dana-Farber Cancer Institute; H. Jack West, MD, a thoracic oncology specialist …

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Loving Partners May Be Key to Breast Cancer Survivors’ Health

WEDNESDAY, June 10, 2020 (HealthDay News) — A little romance may go a long way toward helping breast cancer survivors thrive. New research showed that a strong romantic relationship wasn’t the cure-all, but it was linked to lower psychological stress and lower inflammation, which is a key to staying healthy. “It’s important for survivors, when they’re going through this uncertain …

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‘Lab-on-a-Chip’ Blood Test Could Spot Breast Cancer Early

By Dennis ThompsonHealthDay Reporter WEDNESDAY, June 10, 2020 (HealthDay News) — A cutting-edge “lab-on-a-chip” has shown promise in detecting early breast cancers and tumors that have developed in other parts of the body. Roughly the size of a glass microscope slide, the EV-CLUE uses nanotechnology to pump a tiny amount of blood into eight miniscule channels equipped to detect different …

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Clinical Challenges: HER2-Positive Breast Cancer

The general treatment of advanced HER2-positive breast cancer has typically consisted of a combination of chemotherapy and the monoclonal antibodies trastuzumab and pertuzumab as a first-line treatment, and the antibody-drug conjugate T-DM1 in the second line. “Once these treatments were incorporated into the management of metastatic disease the outcomes of patients improved substantially,” said Ian Krop, MD, PhD, associate chief …

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Increased Risk for Invasive Breast Cancer After DCIS

One of the controversies of routine mammography screening of healthy women is that it detects minimal-risk breast cancer, including the vast majority of ductal carcinoma in situ (DCIS), which has led to concerns of over-diagnosis and over-treatment. This in turn has led to proposals that DCIS could be managed by active surveillance instead of immediate treatment with surgery. But a …

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Add-On Tucatinib Ups Survival in Breast Cancer With Brain Mets

Adding tucatinib (Tukysa) to a trastuzumab-capecitabine (Herceptin-Xeloda) regimen significantly improved central nervous system (CNS) outcomes versus placebo plus trastuzumab-capecitabine in patients with HER2-positive metastatic breast cancer and brain metastases at baseline, researchers reported. In the HER2CLIMB study, the risk of intracranial progression or death was cut by 68% in the tucatinib arm (hazard ratio 0.32, 95% CI 0.22-0.48, P

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Breast Cancer: Higher Progesterone Levels Tied to Increased Risk in Postmenopausal Women

(MedPage Today) — Study Authors: Britton Trabert, Doug C. Bauer, et al.; Seema A. Khan Target Audience and Goal Statement: Oncologists, obstetrician-gynecologists, endocrinologists The goal of this study was to evaluate the association between… Source link : https://www.medpagetoday.org/hematologyoncology/breastcancer/86726 Author : Publish date : 2020-05-28 14:30:00 Copyright for syndicated content belongs to the linked Source.

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New Clue to Anti-PD-L1 Activity in Breast Cancer?

A novel biomarker identified a large subgroup of metastatic breast cancer patients who benefited from an immune checkpoint inhibitor, according to an exploratory analysis of a prospective clinical trial. Almost a fourth of patients with no identified actionable mutations had either copy number alteration (CNA) in the PD-L1 gene. Patients without PD-L1 CNA had a median progression-free survival (PFS) of …

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Did Breast Cancer Radiation Cause This Weird Lung Problem?

A 69-year-old woman with breast cancer presents to hospital in Beirut to receive her first post-mastectomy chemotherapy session. She notes that in the past 6 months, she has received neoadjuvant chemotherapy, had a partial mastectomy of the left breast, and been treated with adjuvant radiotherapy. During admission, however, she reports sudden severe pain in her lower back. Examination finds that …

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Black and White Women Share the Same Genetic Risk for Breast Cancer

TUESDAY, May 19, 2020 (HealthDay News) — Black and white women share genes that increase the risk for breast cancer, a new study finds. These genes include BRCA1, BRCA2 and PALB2, each of which is associated with a more than sevenfold risk of breast cancer. Women of both races also share four other genes linked with a moderately increased risk, …

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